Subcortical Function: Contributions to Hemispheric Asymmetry Reduction in Older Adults
Anna Moore, PhD
AFAR (2005 - 2007)

Objective: To elucidate the neural substrates of hemispheric asymmetry reduction in neural activity in older adults during tasks of verbal working memory.

Research Plan/ Methods: This study will use a neuroimaging technique (functional magnetic resonance imaging) to examine brain activity during working memory. Healthy volunteers between the ages of 18-85 will participate in a series of paper and pencil tests of learning, memory, and attention. Also, they will answer questions about their health history, educational background, hand preference, and native language. Finally, these volunteers will undergo a brain scan while carrying out a working memory task.

Clinical Relevance: Results of this study are expected to help us better understand changes in brain function across the lifespan. It is hoped that this knowledge can be applied to development of rehabilitative techniques older adults can use to assist their working memory skills.